Step 1 – Right-click on an empty area on the Taskbar and select Task Manager. Step 2 – When Task Manager comes up, click the Startup tab and look through the list of programs that are enabled to run during startup. Then to stop them from running, right-click the program and select Disable. If you find that your Mac doesn’t start as quickly as it used to, or your mouse is non-responsive when first turning on and logging in to your computer, you should check for unnecessary launch items. Stop these programs from running on startup, and you might speed up your Mac’s launch process significantly. Jan 10, 2015 · Method 1: How to Directly Change Start-Up Setting of Programs: You monitor that a program keeps starting automatically on start-up, and you want that action to stop, many a times the simplest resolution is to directly explore the program’s settings. Start the program that is automatically starting at startup.